A nanoplatform based on allylthiopurine bio-MOF and glycosylated AIE PARP inhibitor for cancer synthetic lethal therapy-Reference-Cited by-同舟云学术

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A nanoplatform based on allylthiopurine bio-MOF and glycosylated AIE PARP inhibitor for cancer synthetic lethal therapy

Published:2024 Issue:67 Volume:60 Page:8892-8895
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Gao Bingling¹,Yang Ke¹,Yang Manman¹,Li Wendong¹,Jiang Tingli¹,Gao Rong¹,Pei Yuxin¹^ORCID,Pei Zhichao¹^ORCID,Lv Yinghua¹^ORCID

Affiliation:

1. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China

Abstract

A multifunctional nanoplatform (Gal-ANI@ZnAP NPs) based on prodrug-skeletal metal–organic frameworks (ZnAP) functionalized with AIE fluorescent PARP inhibitor glycoconjugates was constructed for drug uptake visualization and synthetic lethal therapy.

Funder

Key Research and Development Projects of Shaanxi Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC02944E

Reference23 articles.

1. DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

2. PARP inhibitors: Synthetic lethality in the clinic

3. DNA repair and synthetic lethality

4. Poly(ADP-ribose) polymerase inhibition: past, present and future

5. Dual stimuli-responsive bispillar[5]arene-based nanoparticles for precisely selective drug delivery in cancer cells

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