How change in chirality prevents β-amyloid type interaction in a protonated cyclic dipeptide dimer-Reference-Cited by-同舟云学术

How change in chirality prevents β-amyloid type interaction in a protonated cyclic dipeptide dimer

Published:2022 Issue:33 Volume:24 Page:19783-19791
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Le Barbu-Debus Katia¹^ORCID,Pérez-Mellor Ariel¹^ORCID,Lepère Valéria¹^ORCID,Zehnacker Anne¹^ORCID

Affiliation:

1. Institut des Sciences Moléculaires d’Orsay (ISMO), CNRS, Université Paris-Saclay, F-91405 Orsay, France

Abstract

The protonated dimer of cyclo (Phe-His) is studied in a ion trap by IR spectroscopy. A β-sheet interaction exists in cyclo (lPhe-lHis) and not in cyclo (lPhe-dHis). A change in chirality of one of the residues thus prevents amyloid-type clustering.

Funder

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D2CP03110H

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