Iodine-promoted amide formation via oxidative cleavage of indoles: novel quinazoline-4(3H)-one and tryptanthrin syntheses

Author:

Le Phong Q.12ORCID,Dinh Van M.3ORCID,Nguyen Huong D. T.42ORCID,Ha Hiep Q.5ORCID,Truong Thanh V.62

Affiliation:

1. School of Biotechnology, International University-VNU HCM, Quarter 6, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, Vietnam

2. Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, Vietnam

3. Department of Chemistry, Chemical-Biological Centre, Umeå University, SE-90187 Umeå, Sweden

4. Faculty of Chemistry, University of Science, 227 Nguyen Van Cu, District 5, Ho Chi Minh City, Vietnam

5. Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University, Ho Chi Minh City 755414, Vietnam

6. Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, 268 Ly Thuong Kiet, District 10, Ho Chi Minh City, Vietnam

Abstract

A highly efficient method for the direct construction of amide bonds via a selective cleavage of C–H and CC bonds in indole structures using an iodine-promoted approach was developed.

Funder

National Foundation for Science and Technology Development

Publisher

Royal Society of Chemistry (RSC)

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