Naturally based pyrazoline derivatives as aminopeptidase N, VEGFR2 and MMP9 inhibitors: design, synthesis and molecular modeling-Reference-Cited by-同舟云学术

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Naturally based pyrazoline derivatives as aminopeptidase N, VEGFR2 and MMP9 inhibitors: design, synthesis and molecular modeling

Published:2024 Issue:31 Volume:14 Page:22434-22448
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Batran Rasha Z.¹^ORCID,Ahmed Eman Y.¹^ORCID,Awad Hanem M.²^ORCID,Abdel Latif Nehad A.¹

Affiliation:

1. Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, 12622, Egypt

2. Tanning Materials and Leather Technology Department, National Research Centre, Dokki, Cairo, 12622, Egypt

Abstract

New naturally based pyrazoline derivatives were investigated as anti-breast cancer agents targeting APN, VEGFR2 and MMP9. The effects on wound healing, cell cycle and apoptosis were evaluated. Docking and ADMET studies were performed as well.

Funder

National Research Centre

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA01801J

Reference44 articles.

1. Metallo-aminopeptidase inhibitors

2. The physics of cancer: the role of physical interactions and mechanical forces in metastasis

3. Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation

4. Inhibition of tumor invasion and extracellular matrix degradation by ubenimex (bestatin)

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