Synthesis and enantioseparation of proline-derived helical polyacetylenes as chiral stationary phases for HPLC

Author:

Shi Ge12345ORCID,Dai Xiao678910,Zhou Yue12345,Zhang Jie12345ORCID,Shen Jun678910ORCID,Wan Xinhua12345ORCID

Affiliation:

1. Beijing National Laboratory for Molecular Sciences

2. Key Laboratory of Polymer Chemistry and Physics of Ministry of Education

3. College of Chemistry and Molecular Engineering

4. Peking University

5. Beijing 100871

6. Polymer Materials Research Center

7. Key Laboratory of Superlight Materials and Surface Technology

8. Ministry of Education

9. College of Materials Science and Chemical Engineering

10. Harbin Engineering University

Abstract

Proline-derived aliphatically substituted polyacetylenes with stable helical conformations exhibit an excellent enantioseparation ability as chiral stationary phases of HPLC.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Reference49 articles.

1. I. Ali and H. Y.Aboul-Enein , Chiral Pollutants: Distribution, Toxicity and Analysis by Chromatography and Capillary Electrophoresis , Wiley , Chichester , 2004

2. A. M. Thayer , Centering On Chirality , C&EN , Washington , 2007

3. Chiral HPLC for efficient resolution of enantiomers

4. State-of-the-art and recent developments of immobilized polysaccharide-based chiral stationary phases for enantioseparations by high-performance liquid chromatography (2013–2017)

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