Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor-Reference-Cited by-同舟云学术

Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor

Published:2023 Issue:26 Volume:59 Page:3838-3841
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

van Dongen Sjoerd W.¹^ORCID,Baglai Iaroslav¹^ORCID,Leeman Michel²^ORCID,Kellogg Richard M.²,Kaptein Bernard³^ORCID,Noorduin Willem L.¹⁴^ORCID

Affiliation:

1. AMOLF, Science Park 104, Amsterdam 1098 XG, The Netherlands

2. Symeres, Kadijk 3, Groningen 9747 AT, The Netherlands

3. InnoSyn BV, Urmonderbaan 22, Geleen 6167 RD, The Netherlands

4. Van’t Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, Amsterdam, The Netherlands

Abstract

Using a Soxhlet-apparatus, we demonstrate that a conglomerate-forming clopidogrel precursor undergoing solution phase racemization can be deracemized through cyclic solvent removal and re-addition.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC00332A

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