Investigations of possible prodrug structures for 2-(2-mercaptophenyl)tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds-Reference-Cited by-同舟云学术

Investigations of possible prodrug structures for 2-(2-mercaptophenyl)tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds

Published:2015 Issue:16 Volume:13 Page:4706-4713
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Okazaki Shiho¹²³⁴,Oishi Shinya¹²³⁴,Mizuhara Tsukasa¹²³⁴,Shimura Kazuya⁵²⁶⁴,Murayama Hiroto⁵²⁶⁴,Ohno Hiroaki¹²³⁴,Matsuoka Masao⁵²⁶⁴,Fujii Nobutaka¹²³⁴

Affiliation:

1. Graduate School of Pharmaceutical Sciences

2. Kyoto University

3. Kyoto 606-8501

4. Japan

5. Institute for Virus Research

6. Kyoto

Abstract

PD 404182 and benzo[4,5]isothiazolo[2,3-a]pyrimidines are possible prodrug forms of the ring-opened thiophenols with anti-HIV activity.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00301F

Reference24 articles.

1. Identification of a Slow Tight-Binding Inhibitor of 3-Deoxy-d-manno-octulosonic Acid 8-Phosphate Synthase

2. Structure, Biochemistry, and Inhibition of Essential 4′-Phosphopantetheinyl Transferases from Two Species of Mycobacteria

3. A Novel and Potent Inhibitor of Dimethylarginine Dimethylaminohydrolase: A Modulator of Cardiovascular Nitric Oxide

4. A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle

5. PD 404,182 Is a Virocidal Small Molecule That Disrupts Hepatitis C Virus and Human Immunodeficiency Virus

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