Direct access to isoxazolino and isoxazolo benzazepines from 2-((hydroxyimino)methyl)benzoic acid via a post-Ugi heteroannulation

Author:

Balalaie Saeed12345ORCID,Shamakli Mohammad1234,Nikbakht Ali1234,Alavijeh Nahid S.1234,Rominger Frank678,Rostamizadeh Shahnaz1234,Bijanzadeh Hamid Reza91034

Affiliation:

1. Peptide Chemistry Research Center

2. K. N. Toosi University of Technology

3. Tehran

4. Iran

5. Medical Biology Research Center

6. Organisch-Chemisches Institut der Universität Heidelberg

7. D-69120 Heidelberg

8. Germany

9. Department of Biophysics

10. Tarbiat Modares University

Abstract

A diversity-oriented access to isoxazolino and isoxazolo benzazepines is elaborated via a post-Ugi heteroannulation involving intramolecular 1,3-dipolar cycloaddition reaction of nitrile oxides with alkenes and alkynes.

Funder

Iran National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference31 articles.

1. T. J. J. Müller , in Synthesis of Heterocycles via Multicomponent Reactions II, ed. R. V. Orru and E. Ruijter, Springer, Berlin, 2010, ch. 1, pp. 25–94

2. Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics

3. S. Marcaccini and T.Torroba, in Multicomponent Reactions, ed. J. Zhu and H. Bienayme, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2005, ch. 2, pp. 33–75

4. Chemistry and Biology Of Multicomponent Reactions

5. Multicomponent Reactions, Union of MCRs and Beyond

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