N-Heterocyclic carbene catalyzed base assisted C–C bond cleavage of cyclopropenones: an approach towards diastereoselective synthesis of azetidinones and benzoxazepines-Reference-Cited by-同舟云学术

N-Heterocyclic carbene catalyzed base assisted C–C bond cleavage of cyclopropenones: an approach towards diastereoselective synthesis of azetidinones and benzoxazepines

Published:2023 Issue:24 Volume:10 Page:6166-6171
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Nanda Tanmayee¹²,Shukla Asish Dharmendra¹²,Dhal Shubham Kumar¹²,Fastheem Muhammed¹²,Ravikumar Ponneri C.¹²^ORCID

Affiliation:

1. School of Chemical Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar, Odisha 752050, India

2. Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India

Abstract

We have demonstrated a synthetic protocol to synthesize two different bio-active skeletons, that is, β-lactam and benzoxazepine by using N-heterocyclic carbene as the catalyst. Herein, 3-membered strained cyclopropenone has been used as a 3C synthon.

Funder

National Institute of Science Education and Research

Department of Atomic Energy, Government of India

Council of Scientific and Industrial Research, India

University Grants Commission

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO01328F