Conformational flexibility driving charge-selective substrate translocation across a bacterial transporter-Reference-Cited by-同舟云学术

Conformational flexibility driving charge-selective substrate translocation across a bacterial transporter

Published:2024 Issue:24 Volume:15 Page:9333-9344
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Vikraman Devika¹²,Majumdar Bibhab Bandhu³,SK Sharavanakkumar¹,Weichbrodt Conrad⁴,Fertig Niels⁴,Winterhalter Mathias⁵⁶,Mondal Jagannath⁷^ORCID,Mahendran Kozhinjampara R.¹^ORCID

Affiliation:

1. Transdisciplinary Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695014, India

2. Manipal Academy of Higher Education, Manipal, Karnataka-576104, India

3. School of Advanced Sciences, VIT-AP University, Amaravati, Andhra Pradesh 522237, India

4. Nanion Technologies GmbH, Munich, 80339, Germany

5. School of Science, Constructor University, Campus Ring 1, 28759 Bremen, Germany

6. Center for Hybrid Nanostructures (CHyN), Universität Hamburg, Luruper Chaussee 149, Hamburg 22761, Germany

7. Tata Institute of Fundamental Research, Hyderabad, Telangana-500046, India

Abstract

Here, we establish the conformational dynamics of a specialized natural passive bacterial transporter, CymA, using single-channel recordings and molecular dynamics simulations.

Funder

Science and Engineering Research Board

Department of Atomic Energy, Government of India

Rajiv Gandhi Centre for Biotechnology, Department of Biotechnology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC00345D

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