Dual-responsive probe and DNA interstrand crosslink precursor target the unique redox status of cancer cells

Author:

Yu Dehao1,Wang Luo1,Li Jingao1,Zeng Xuanwei1,Jia Yuanyuan1,Tian Junyu1,Campbell Anahit2,Sun Huabing1ORCID,Fan Heli1ORCID

Affiliation:

1. The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, P. R. China

2. Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA

Abstract

Elevated GSH and H2O2 in some cancer cells is confirmed, and employed for the development of dual-responsive DNA ICL precursor.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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