Conformational control of antimicrobial peptide amphiphilicity: consequences for boosting membrane interactions and antimicrobial effects of photocatalytic TiO2 nanoparticles

Author:

Caselli Lucrezia1ORCID,Köhler Sebastian2,Schirone Davide3,Humphreys Ben4,Malmsten Martin15ORCID

Affiliation:

1. Department of Physical Chemistry 1, Lund University, SE-22100 Lund, Sweden

2. LINXS Institute of Advanced Neutron and X-ray Science, Scheelevagen 19, 22370 Lund, Sweden

3. Department of Biomedical Sciences and Biofilms-Research Center for Biointerfaces (BRCB), Malmö University, 20506 Malmö, Sweden

4. Institut Laue–Langevin, CS 20156, 38042 Grenoble Cedex 9, France

5. Department of Pharmacy, University of Copenhagen, DK-2100 Copenhagen, Denmark

Abstract

Conformationally controlled amphiphilicity of antimicrobial peptides affects their ability to coat photocatalytic TiO2 nanoparticles (NPs) and controls membrane interactions of peptide-coated TiO2 NPs, boosting their antimicrobial effects.

Funder

Institut Laue-Langevin

Vetenskapsrådet

Danmarks Frie Forskningsfond

LEO Fondet

Publisher

Royal Society of Chemistry (RSC)

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