A molecular journey to check the conformational dynamics of tau tubulin kinase 2 mutations associated with Alzheimer's disease
Author:
Affiliation:
1. Translational Bioinformatics Group
2. International Centre for Genetic Engineering and Biotechnology (ICGEB)
3. New Delhi 110067
4. India
5. Amity Institute of Neuropsychology & Neurosciences
6. Amity University
7. Noida
Abstract
MD simulations of TTBK2 mutants to study its impact on stability of the protein.
Funder
Indian Council of Medical Research
Department of Biotechnology, Ministry of Science and Technology, India
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA07659G
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1. Structural insight into microtubule stabilization and kinesin inhibition by Tau family MAPs
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4. Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease—From Brain Starch to Bench and Bedside
5. The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43
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