High-throughput single-cell assay for precise measurement of the intrinsic mechanical properties and shape characteristics of red blood cells

Author:

Wei Qiaodong1ORCID,Xiong Ying2,Ma Yuhang3,Liu Deyun1,Lu Yunshu4,Zhang Shenghong1,Wang Xiaolong1,Huang Huaxiong567,Liu Yingbin8,Dao Ming910ORCID,Gong Xiaobo111ORCID

Affiliation:

1. Key Laboratory of Hydrodynamics (Ministry of Education), Department of Engineering Mechanics, School of Naval Architecture Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai 200240, China

2. Obstetrics and Gynecology Department, Xinhua Hospital Affiliated to Shanghai Jiao Tong University Medical School, Shanghai 200240, China

3. Endocrinology Department, Shanghai General Hospital, Shanghai 200240, China

4. Department of Breast Surgery, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200433, China

5. Research Center for Mathematics, Advanced Institute of Natural Sciences, Beijing Normal University, Zhuhai, Guangdong, 519088, China

6. Guangdong Provincial Key Laboratory of Interdisciplinary Research and Application for Data Science, BNU-HKBU United International College, Zhuhai, Guangdong, 519088, China

7. Department of Mathematics and Statistics York University, Toronto, ON, M3J 1P3, Canada

8. Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

9. Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

10. School of Biological Sciences, Nanyang Technological University, 637551, Singapore

11. State Key Laboratory of Ocean Engineering, School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai 200240, China

Abstract

A unique high-throughput single-cell microfluidic method for measuring the inherent physical/mechanical properties of RBCs.

Funder

National Natural Science Foundation of China

Shanghai Jiao Tong University

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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