Investigation of the metabolic stability of olmutinib by validated LC-MS/MS: quantification in human plasma
Author:
Affiliation:
1. Department of Pharmaceutical Chemistry
2. College of Pharmacy
3. King Saud University
4. Riyadh
5. Kingdom of Saudi Arabia
Abstract
Olmutinib (OTB, Olita™) is an orally available third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI).
Funder
King Saud University
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA08161A
Reference21 articles.
1. Cancer Statistics, 2008
2. From Bench Top to Bedside
3. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
4. Non–Small Cell Lung Cancer
5. Targeted Therapies for Lung Cancer
Cited by 29 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Evaluation of Alectinib Metabolic Stability in HLMs Using Fast LC-MS/MS Method: In Silico ADME Profile, P450 Metabolic Lability, and Toxic Alerts Screening;Pharmaceutics;2023-10-11
2. Current Bioanalysis of Molecularly Targeted Drugs Using Liquid Chromatography–Tandem Mass Spectrometry;CHROMATOGRAPHY;2023-06-20
3. An LC–MS/MS Analytical Method for Quantifying Tepotinib in Human Liver Microsomes: Application to In Vitro and In Silico Metabolic Stability Estimation;Separations;2023-05-26
4. Instability Mechanism of Osimertinib in Plasma and a Solving Strategy in the Pharmacokinetics Study;Frontiers in Pharmacology;2022-07-22
5. A rapid and sensitive LC-MS/MS method for determination of the active component K6 in serum of patients with depression;Journal of Pharmaceutical and Biomedical Analysis;2022-05
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3