Genome mining and biosynthesis of kitacinnamycins as a STING activator

Author:

Shi Jing12345,Liu Cheng Li12345,Zhang Bo12345,Guo Wen Jie12345,Zhu Jiapeng6785,Chang Chin-Yuan9101112,Zhao Er Juan12345,Jiao Rui Hua12345,Tan Ren Xiang12345ORCID,Ge Hui Ming12345ORCID

Affiliation:

1. State Key Laboratory of Pharmaceutical Biotechnology

2. Institute of Functional Biomolecules

3. School of Life Sciences

4. Nanjing University

5. P. R. China

6. State Key Laboratory Cultivation Base for TCM Quality and Efficacy

7. Nanjing University of Chinese Medicine

8. Nanjing 210023

9. Department of Biological Science and Technology

10. National Chiao Tung University

11. Hsinchu

12. Republic of China

Abstract

Genome mining targeting unique type II PKS and NRPS led to the identification of a novel class of glycopeptides named kitacinnamycins.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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