A synthesized butyrolactone derivative in combination with chloroquine can inhibit cancer cell growth and lysosome vacuolation induced by chloroquine in A549 lung cancer cells
Author:
Affiliation:
1. Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology
2. School of Life Science
3. Shandong University
4. Jinan 250100
5. China
6. Institute of Organic Chemistry
7. School of Chemistry and Chemical Engineering
Abstract
3BDO in combination with chloroquine could elevate the Na+,K+-ATPase activity and decrease the expression of competing endogenous non-coding RNA TGFB2-OT1. Therefore, the combination inhibited the cells growth and lysosomal vacuolation induced by CQ.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA02533A
Reference26 articles.
1. Metabolic Control of Autophagy
2. Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy
3. Malaria Chemotherapeutics Part I: History of Antimalarial Drug Development, Currently Used Therapeutics, and Drugs in Clinical Development
4. Time to use a dose of Chloroquine as an adjuvant to anti-cancer chemotherapies
5. Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells
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