A low toxic synthetic dendrimer conjugated podophyllotoxin nanodevice with potent antitumor activity against the DMBA/TPA induced mouse skin carcinogenesis model-Reference-Cited by-同舟云学术

A low toxic synthetic dendrimer conjugated podophyllotoxin nanodevice with potent antitumor activity against the DMBA/TPA induced mouse skin carcinogenesis model

Published:2015 Issue:5 Volume:4 Page:1204-1213
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Sk Ugir Hossain¹²³⁴,Patial Vikram⁵²³⁴,Sharma Supriya⁵²³⁴

Affiliation:

1. Natural Products Chemistry and Process Development Division

2. Institute of Himalayan Bioresource Technology

3. Palampur

4. India

5. Regulatory Research Centre

Abstract

D-PODO in tumor-bearing mice revealed a 50%–60% inhibition of skin tumor formation and reduced toxicity compared to PODO.

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/TX/C5TX00112A

Reference41 articles.

1. Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives

2. Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring

3. Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents

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