Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support-Reference-Cited by-同舟云学术

Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support

Published:2021 Issue:7 Volume:11 Page:3892-3896
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Suchsland Ruth¹²³⁴,Appel Bettina¹²³⁴^ORCID,Virta Pasi⁵⁶⁷⁸^ORCID,Müller Sabine¹²³⁴^ORCID

Affiliation:

1. University Greifswald

2. Institute for Biochemistry

3. 17487 Greifswald

4. Germany

5. University of Turku

6. Department of Chemistry

7. 20014 Turku

8. Finland

Abstract

Fully protected trinucleotides are synthesized on a tetrapodal soluble support using a disulphide linkage that upon reductive cleavage allows release of the trinucleotide with free 3′-OH group for further conversion to a phosphoramidite.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA10941J

Reference32 articles.

1. Trinucleotide phosphoramidites: ideal reagents for the synthesis of mixed oligonucleotides for random mutagenesis

2. Developments in Directed Evolution for Improving Enzyme Functions

3. Random Mutagenesis Methods for In Vitro Directed Enzyme Evolution

4. Preparation of trinucleotide phosphoramidites as synthons for the synthesis of gene libraries

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1. Tuning the Solubility of Soluble Support Constructs in Liquid Phase Oligonucleotide Synthesis;The Journal of Organic Chemistry;2024-09-09

2. 5'‐O‐(2‐Isopropoxyprop‐2‐yl)‐protected Phosphoramidite Building Blocks in the Liquid Phase Oligonucleotide Synthesis;European Journal of Organic Chemistry;2023-08-11

3. Stereo-Controlled Liquid Phase Synthesis of Phosphorothioate Oligonucleotides on a Soluble Support;The Journal of Organic Chemistry;2023-07-10

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