A small-sized benzothiazole–indolium fluorescent probe: the study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging-Reference-Cited by-同舟云学术

A small-sized benzothiazole–indolium fluorescent probe: the study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

Published:2020 Issue:95 Volume:56 Page:15016-15019
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zheng Bo-Xin¹²³⁴,She Meng-Ting¹²³⁴,Long Wei¹²³⁴,Xu Yong-Yu¹²³⁴,Zhang Yi-Han¹²³⁴,Huang Xuan-He¹²³⁴,Liu Wenjie⁵⁶⁷⁸,Hou Jin-Qiang⁵⁶⁷⁸,Wong Wing-Leung⁹¹⁰¹¹¹²¹³^ORCID,Lu Yu-Jing¹²³⁴^ORCID

Affiliation:

1. School of Biomedical and Pharmaceutical Sciences

2. Guangdong University of Technology

3. Guangzhou 510006

4. P. R. China

5. Department of Chemistry

6. Lakehead University and Thunder Bay Regional Health Research Institute

7. Thunder Bay

8. Canada

9. State Key Laboratory of Chemical Biology and Drug Discovery

10. Department of Applied Biology Chemical Technology

11. The Hong Kong Polytechnic University

12. Kowloon

13. China

Abstract

A small-sized and target-specific fluorescent probe reveals the presence of c-MYC DNA G4-structures in cells and shows anticancer activity.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC06525K

Reference24 articles.

1. Single-molecule visualization of DNA G-quadruplex formation in live cells

2. Real-time monitoring of DNA G-quadruplexes in living cells with a small-molecule fluorescent probe

3. G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications

4. Green Fluorescent Protein as a Marker for Gene Expression

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