Engineering cell-free systems by chemoproteomic-assisted phenotypic screening-Reference-Cited by-同舟云学术

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Engineering cell-free systems by chemoproteomic-assisted phenotypic screening

Published:2024 Issue:4 Volume:5 Page:372-385
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Levitskaya Zarina¹,Ser Zheng²,Koh Hiromi²^ORCID,Mei Wang Shi²,Chee Sharon¹,Sobota Radoslaw Mikolaj²,Ghadessy John F.¹^ORCID

Affiliation:

1. Protein and Peptide Engineering and Research Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Singapore, 138648

2. Function Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Singapore, 138648

Abstract

Phenotypic screening identified drugs capable of improving the yeast lysate cell-free protein synthesis (CFPS) yield. A drug target gene identified using mass spectrometry proteomics was deleted to yield a yeast strain with higher productivity CFPS.

Funder

National Research Foundation Singapore

Agency for Science, Technology and Research

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CB/D4CB00004H

Reference94 articles.

1. Phenotypic drug discovery: recent successes, lessons learned and new directions

2. Neoclassic Drug Discovery

3. Chemoproteomic-enabled phenotypic screening

4. The discovery of first-in-class drugs: origins and evolution

5. Cell-free protein synthesis: Applications come of age

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