Design and synthesis of berberine loaded nano-hydroxyapatite/gelatin scaffold for bone cancer treatment

Author:

Khajavi Sajjad1,Bahraminasab Marjan23ORCID,Arab Samaneh3,Talebi Athar2,Kokhaei Parviz45,Abdoos Hassan6

Affiliation:

1. Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran

2. Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan 35147-99442, Iran

3. Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Semnan University of Medical Sciences, Semnan 35147-99442, Iran

4. BioClinicum, Department of Oncology-Pathology, Karolinska University Hospital Solna, Stockholm, Sweden

5. Department of Immunology, Arak University of Medical Sciences, Arak, Iran

6. Department of Nanotechnology, Faculty of New Sciences and Technologies, Semnan University, Semnan 35131-19111, Iran

Abstract

A tissue engineered BBR-loaded nano-HA/gelatin scaffold, as a local drug delivery system, was developed with the aim to be implanted after surgery for osteosarcoma treatment, mimicking the natural tissue ECM, and releasing BBR as an anticancer drug.

Funder

Semnan University of Medical Sciences and Health Services

Publisher

Royal Society of Chemistry (RSC)

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