A new class of prophylactic metallo-antibiotic possessing potent anti-cancer and anti-microbial properties-Reference-Cited by-同舟云学术

A new class of prophylactic metallo-antibiotic possessing potent anti-cancer and anti-microbial properties

Published:2019 Issue:24 Volume:48 Page:8578-8593
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Ude Ziga¹²³⁴⁵,Kavanagh Kevin⁶⁷⁸⁵,Twamley Brendan⁹¹⁰¹¹⁴⁵,Pour Milan¹²¹³¹⁴¹⁵¹⁶^ORCID,Gathergood Nicholas¹⁷¹⁸¹⁹²⁰²¹^ORCID,Kellett Andrew²²²³²⁴⁵^ORCID,Marmion Celine J.¹²³⁴⁵^ORCID

Affiliation:

1. Centre for Synthesis and Chemical Biology

2. Department of Chemistry

3. Royal College of Surgeons in Ireland

4. Dublin 2

5. Ireland

6. Department of Biology

7. Maynooth University

8. Maynooth

9. School of Chemistry

10. Trinity College Dublin

11. University of Dublin College Green

12. Department of Organic and Bioorganic Chemistry

13. Faculty of Pharmacy

14. Charles University

15. 500 05 Hradec Kralove

16. Czech Republic

17. ERA Chair of Green Chemistry

18. Division of Chemistry

19. Department of Chemistry and Biotechnology

20. School of Science

21. Tallinn University of Technology

22. School of Chemical Sciences and the National Institute for Cellular Biotechnology

23. Dublin City University

24. Dublin 9

Abstract

A family of metallo-antibiotics of general formula [Cu(N,N)(CipA)Cl] where N,N is a phenanthrene ligand and CipA is a derivative of the clinically used fluoroquinolone antibiotic ciprofloxacin – targeting immunocompromised cancer patients undergoing chemotherapy.

Funder

Science Foundation Ireland

Royal College of Surgeons in Ireland

European Regional Development Fund

Horizon 2020 Framework Programme

H2020 Marie Skłodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/DT/C9DT00250B