Bioorthogonal dissociative rhenium(i) photosensitisers for controlled immunogenic cell death induction

Author:

Xu Guang-Xi1ORCID,Lee Lawrence Cho-Cheung12ORCID,Leung Peter Kam-Keung13ORCID,Mak Eunice Chiu-Lam1ORCID,Shum Justin1ORCID,Zhang Kenneth Yin4ORCID,Zhao Qiang4ORCID,Lo Kenneth Kam-Wing13ORCID

Affiliation:

1. Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China

2. Laboratory for Synthetic Chemistry and Chemical Biology Limited, Units 1503-1511, 15/F, Building 17 W, Hong Kong Science Park, New Territories, Hong Kong, P. R. China

3. State Key Laboratory of Terahertz and Millimetre Waves, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China

4. State Key Laboratory of Organic Electronics and Information Displays, Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, P. R. China

Abstract

Rhenium(i) complexes modified with a tetrazine carbamate group were designed as bioorthogonally dissociative photosensitisers for the controlled induction of immunogenic cell death (ICD) after treatment with trans-cyclooct-4-enol and light.

Funder

Innovation and Technology Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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