Combination of Lacticaseibacillus paracasei BEPC22 and Lactiplantibacillus plantarum BELP53 attenuates fat accumulation and alters the metabolome and gut microbiota in mice with high-fat diet-induced obesity

Author:

Lee Na-Rae1ORCID,Kwon Tae-Jun2,Chung Eui-Chun3,Bae Jaewoong3,Soung Song-Hui4,Tak Hyun-Ji4,Choi Jun-Young2,Lee Young-Eun5,Won Hwang Nak3,Lee Jong Seo3,Shin Kum-Joo3,Lee Choong Hwan14,Kim KilSoo26,Kim Seokjin3ORCID

Affiliation:

1. Research Institute for Bioactive-Metabolome Network, Konkuk University, Seoul 05029, Republic of Korea

2. Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI Hub), Daegu 41061, Republic of Korea

3. R&D Center, Hecto Healthcare Co., Ltd, Seoul 06142, Republic of Korea

4. Department of Bioscience and Biotechnology, Konkuk University, Seoul 05209, Republic of Korea

5. Cognitive Science Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea

6. College of Veterinary Medicine, Kyungpook National University, 80 Daehakro, Buk-gu, Daegu 41566, Korea

Abstract

This study evaluated the effects of formulations with Lacticaseibacillus paracasei BEPC22 and Lactiplantibacillus plantarum BELP53 on adiposity, the alteration of microbiota, and the metabolome in high-fat diet-fed mice.

Funder

Ministry of Trade, Industry and Energy

Korea Evaluation Institute of Industrial Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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