A cascade process for directly converting nitriles (RCN) to cyanamides (RNHCN) via SO2F2-activated Tiemann rearrangement

Author:

Zhang Guofu1234,Zhao Yiyong1234,Ding Chengrong1234ORCID

Affiliation:

1. College of Chemical Engineering

2. Zhejiang University of Technology

3. Hangzhou 310014

4. P. R. China

Abstract

A one-pot transition metal-free methodology for cyanamide preparation using readily available materials with easy work-up, wide substrate scope and great functional group-tolerability up to the gram scale.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference64 articles.

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2. A. Ricci , Amino Group Chemistry From Synthesis to the Life Sciences , Wiley-VCH , Weinheim , 2008

3. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy

4. Novel, Nonpeptidic Cyanamides as Potent and Reversible Inhibitors of Human Cathepsins K and L

5. A. G. Gilman , L. S.Goodman , T. W.Rall and F.Murad , Goodman and Gilman's The Pharmacological Basis of Therapeutics , Pergmon Press , New York , 7th edn, 1990

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