Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing-Reference-Cited by-同舟云学术

Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing

Published:2022 Issue:9 Volume:4 Page:2107-2123
ISSN:2516-0230
Container-title:Nanoscale Advances
language:en
Short-container-title:Nanoscale Adv.

Author:

Sarode Apoorva¹^ORCID,Fan Yuchen¹^ORCID,Byrnes Amy E.²,Hammel Michal³,Hura Greg L.³⁴,Fu Yige¹,Kou Ponien¹,Hu Chloe¹,Hinz Flora I.²,Roberts Jasmine²,Koenig Stefan G.¹,Nagapudi Karthik¹,Hoogenraad Casper C.²,Chen Tao¹,Leung Dennis¹,Yen Chun-Wan¹^ORCID

Affiliation:

1. Small Molecule Pharmaceutical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA-94080, USA

2. Department of Neuroscience, Genentech, Inc., South San Francisco, CA 94080, USA

3. Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Lab, Berkeley, CA, USA

4. Chemistry and Biochemistry Department, University of California Santa Cruz, Santa Cruz, CA, USA

Abstract

Development of a high throughput screening workflow to characterize the impact of unique PEG-lipid parameters on oligonucleotide-loaded lipid nanoparticle structure and function.

Funder

Biological and Environmental Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NA/D1NA00712B

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