Core vs. surface labelling of mesoporous silica nanoparticles: advancing the understanding of nanoparticle fate and design of labelling strategies

Author:

Ramírez María de los Ángeles12,Martínez-Villacorta Ángel Manuel13,Gómez-Vallejo Vanessa3,Andreozzi Patricia1,Soler-Illia Galo2,Llop Jordi3ORCID,Moya S. E.1ORCID

Affiliation:

1. Soft Matter Nanotechnology Group, CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramón 194, 20014 San Sebastián, Guipúzcoa, Spain

2. Instituto de Nanosistemas, UNSAM, CONICET, Avenida 25 de Mayo 1021, 1650 San Martín, Buenos Aires, Argentina

3. Radiochemistry and Nuclear Imaging Group, CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramón 194, 20014 San Sebastián, Guipúzcoa, Spain

Abstract

Mesoporous silica nanoparticles modified with peptides for targeting cancer tissue are radiolabeled in the core or in the targeting peptide. Advanced information on the fate of the nanoparticles is obtained comparing biodistribution patterns.

Funder

Ministerio de Ciencia e Innovación

Fondo para la Investigación Científica y Tecnológica

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

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