Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products-Reference-Cited by-同舟云学术

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

Published:2015 Issue:8 Volume:32 Page:1249-1266
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Kibble Milla¹²³⁴,Saarinen Niina⁵⁶⁷⁴,Tang Jing¹²³⁴,Wennerberg Krister¹²³⁴,Mäkelä Sari⁵⁶⁷⁴,Aittokallio Tero¹²³⁴

Affiliation:

1. Institute for Molecular Medicine Finland (FIMM)

2. Biomedicum Helsinki 2U

3. 00014 University of Helsinki

4. Finland

5. Institute of Biomedicine

6. Turku Center for Disease Modeling & Functional Foods Forum

7. 20014 University of Turku

Abstract

This article reviews key network pharmacology concepts and recent experimental–computational approaches that have been successfully applied to natural product research, including unbiased elucidation of mechanisms of action and systematic prediction of effective therapeutic combinations.

Funder

Suomen Akatemia

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/NP/C5NP00005J

Reference115 articles.

1. Botanical Drugs, Synergy, and Network Pharmacology: Forth and Back to Intelligent Mixtures

2. Natural products in drug discovery

3. Phenotypic vs. Target-Based Drug Discovery for First-in-Class Medicines