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Harnessing polarity and viscosity to identify green binary solvent mixtures as viable alternatives to DMF in solid-phase peptide synthesis

  • Published:2021 Issue:9 Volume:23 Page:3295-3311
  • ISSN:1463-9262
  • Container-title:Green Chemistry
  • language:en
  • Short-container-title:Green Chem.

Author:

Martin Vincent1234ORCID,Jadhav Sandip567ORCID,Egelund Peter H. G.1234,Liffert Raphael567,Johansson Castro Henrik1234ORCID,Krüger Tobias567,Haselmann Kim F.1894,Thordal Le Quement Sebastian1234,Albericio Fernando1011121314ORCID,Dettner Frank567,Lechner Carolin567,Schönleber Ralph567ORCID,Pedersen Daniel Sejer1234ORCID

Affiliation:

1. Novo Nordisk A/S

2. CMC API Development

3. DK-2880 Bagsværd

4. Denmark

5. Bachem AG

6. 4416 Bubendorf

7. Switzerland

8. GRT MS Characterisation

9. DK-2760 Måløv

10. School of Chemistry and Physics

11. University of KwaZulu-Natal

12. University Road

13. Durban

14. South Africa

Abstract

Binary solvent mixtures with a suitable polarity and viscosity profile are viable green alternatives to DMF in solid-phase peptide synthesis.

Funder

Novo Nordisk

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry
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