A self-assembled DNA-nanoparticle with a targeting peptide for hypoxia-inducible gene therapy of ischemic stroke-Reference-Cited by-同舟云学术

A self-assembled DNA-nanoparticle with a targeting peptide for hypoxia-inducible gene therapy of ischemic stroke

Published:2019 Issue:5 Volume:7 Page:2174-2190
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Oh Jungju¹²³⁴⁵,Lee Jaewon¹²³⁴⁵,Piao Chunxian¹²³⁴⁵,Jeong Ji Hoon⁶⁷⁸⁵,Lee Minhyung¹²³⁴⁵^ORCID

Affiliation:

1. Department of Bioengineering

2. College of Engineering

3. Hanyang University

4. Seoul 04763

5. Korea

6. College of Pharmacy

7. Sungkyunkwan University

8. Suwon 16419

Abstract

A self-assembled nanoparticle composed of hypoxia-specific anti-RAGE peptide (HSAP), heme oxygenase-1 plasmid (pHO1), and deoxycholate-conjugated polyethylenimine-2k (DP2k) was developed for ischemic stroke therapy.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2019/BM/C8BM01621F

Reference53 articles.

1. Current practice and future directions in the diagnosis and acute treatment of ischaemic stroke

2. Mitochondria, oxidative metabolism and cell death in stroke

3. Hypoxia as a target for tissue specific gene therapy

4. Targets for Vascular Protection After Acute Ischemic Stroke

5. Therapeutic effects of a reducible poly (oligo-d-arginine) carrier with the heme oxygenase-1 gene in the treatment of hypoxic-ischemic brain injury

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