From plant to cancer drug: lessons learned from the discovery of taxol

Author:

Cech Nadja B.1ORCID,Oberlies Nicholas H.1ORCID

Affiliation:

1. University of North Carolina Greensboro, USA

Abstract

This Viewpoint describes events during the 1960s and 1970s that led to the discovery of taxol, which remains one of the most effective treatments for breast and ovarian cancer. We highlight lessons relevant to natural products drug discovery today.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference18 articles.

1. G. M.Cragg , M. R.Boyd , J. H.Cardellina 2nd , D. J.Newman , K. M.Snader and T. G.McCloud , Ciba Foundation Symposium , 1994 , vol. 185 , pp. 178–190 ; discussion 190-176

2. D. G. I.Kingston , personal communication , Greensboro, NC , September 11, 2015

3. Scientific and Regulatory Approach to Botanical Drug Development: A U.S. FDA Perspective

4. Patenting natural products just got harder

5. Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2

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