Scalemic natural products

Author:

Mazzotta Sarah1,Rositano Vincenzo12,Senaldi Luca2,Bernardi Anna1ORCID,Allegrini Pietro2,Appendino Giovanni3ORCID

Affiliation:

1. Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy

2. Indena SpA, Via Don Minzoni 6, 20049 Settala, MI, Italy

3. Dipartimento di Scienze del Farmaco, Largo Donegani 2, 28100 Novara, Italy

Abstract

In natural products, a low optical purity is not generally associated with a sloppy enzymatic activity, but rather with the co-expression of antipodal enzymes/directing proteins or, alternatively, with erosion by enzymatic or spontaneous reactions.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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