A novel ruthenium(ii) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells

Author:

Graminha Angelica E.12345ORCID,Honorato João1234ORCID,Correa Rodrigo S.1674,Cominetti Marcia R.5234ORCID,Menezes Antônio C. S.89104,Batista Alzir A.1234ORCID

Affiliation:

1. Departamento de Química

2. Universidade Federal de São Carlos – UFSCar

3. São Carlos

4. Brazil

5. Departamento de Gerontologia

6. Universidade Federal de Ouro Preto (UFOP)

7. Ouro Preto MG

8. Centro de Ciências Exatas e de Tecnologia

9. Universidade Estadual de Goiás – UEG

10. Anápolis

Abstract

Ru(ii) complexes with gallic acid and derivatives interact with biomolecules and show high SI among non-tumor/tumor breast cells. The gallic acid complex causes damage to the cell cytoskeleton inhibiting adhesion, invasion, and migration of tumor cells.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Reference58 articles.

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2. J. K. Sahni , L.Letenneur , L. H.Dao and C.Ramassamy , in Lifetime Nutritional Influences on Cognition, Behaviour and Psychiatric Illness , Elsevier , 2011 , pp. 392–419

3. J. Cvejić Hogervorst , M.Atanacković Krstonošić , M.Bursać and U.Miljić , in Nutraceutical and Functional Food Components , Elsevier , 2017 , pp. 203–258

4. Gallic acid: a versatile antioxidant with promising therapeutic and industrial applications

5. Gallic acid as the major antioxidant in pequi (Caryocar brasiliense Camb.) fruit peel

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