Dearomative cyclization of pyridines/isoquinolines with cyclopropenones: access to indolizinones and benzo-fused indolizinones-Reference-Cited by-同舟云学术

Dearomative cyclization of pyridines/isoquinolines with cyclopropenones: access to indolizinones and benzo-fused indolizinones

Published:2023 Issue:27 Volume:59 Page:4051-4054
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Liu Xiang¹^ORCID,Shi Xiaotian¹,Zhou Jinlei¹,Huang Changfeng¹,Lin Yu¹,Zhang Chen¹²,Cao Hua¹^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering and Guangdong Cosmetics Engineering & Technology Research Center, Guangdong Pharmaceutical University, Zhongshan 528458, China

2. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China

Abstract

Herein, we report an efficient dearomative [3+2] cycloaddition reaction of 2-alkynyl pyridines with diarylcyclopropenones, leading to the synthesis of densely functionalized indolizinones in moderate to good yields under metal-free conditions.

Funder

Guangdong Pharmaceutical University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC00492A

Reference66 articles.

1. Recent advances in chemical dearomatization of nonactivated arenes

2. Group 6 Dihapto-Coordinate Dearomatization Agents for Organic Synthesis

3. Catalytic Asymmetric Dearomatization Reactions

4. Chiral phosphoric acid-catalyzed asymmetric dearomatization reactions

5. Visible-light induced dearomatization reactions

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