Multi-dimensional LC-MS: the next generation characterization of antibody-based therapeutics by unified online bottom-up, middle-up and intact approaches-Reference-Cited by-同舟云学术

Multi-dimensional LC-MS: the next generation characterization of antibody-based therapeutics by unified online bottom-up, middle-up and intact approaches

Published:2021 Issue:3 Volume:146 Page:747-769
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Camperi Julien¹²³⁴^ORCID,Goyon Alexandre⁵²³⁴,Guillarme Davy⁶⁷⁸⁹¹⁰^ORCID,Zhang Kelly⁵²³⁴,Stella Cinzia¹²³⁴

Affiliation:

1. Department of Protein Analytical Chemistry

2. Genentech Inc.

3. South San Francisco

4. USA

5. Department of Small Molecule Analytical Chemistry

6. School of Pharmaceutical Sciences

7. University of Geneva

8. 1206 Geneva

9. Switzerland

10. Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO)

Abstract

This review presents an overview of current analytical trends in antibody characterization by multidimensional LC-MS approaches.

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/AN/D0AN01963A

Reference132 articles.

1. 2019 FDA drug approvals

2. Antibodies to watch in 2020

3. Recent advances in LC–MS based characterization of protein-based bio-therapeutics – mastering analytical challenges posed by the increasing format complexity

4. Unraveling the mysteries of modern size exclusion chromatography - the way to achieve confident characterization of therapeutic proteins

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