Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity-Reference-Cited by-同舟云学术

Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity

Published:2017 Issue:10 Volume:8 Page:1934-1945
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Nedopekina Darya A.¹²³⁴^ORCID,Gubaidullin Rinat R.¹²³⁴,Odinokov Victor N.¹²³⁴^ORCID,Maximchik Polina V.⁵⁶⁷⁸,Zhivotovsky Boris⁵⁶⁷⁸⁹^ORCID,Bel'skii Yuriy P.¹⁰¹¹⁴,Khazanov Veniamin A.¹⁰¹¹⁴,Manuylova Arina V.¹⁰¹¹⁴,Gogvadze Vladimir⁵⁶⁷⁸⁹,Spivak Anna Yu.¹²³⁴^ORCID

Affiliation:

1. Institute of Petrochemistry and Catalysis

2. Russian Academy of Sciences

3. Ufa 450075

4. Russian Federation

5. Faculty of Fundamental Medicine

6. MV Lomonosov Moscow State University

7. 11999 Moscow

8. Russia

9. Division of Toxicology

10. Innovative Pharmacology Research (IPHAR)

11. Tomsk 634021

Abstract

Conjugation of native triterpenoids, namely, betulinic and ursolic acids, with a lypophilic triphenylphosphonium cation led to the dramatic enhancement, as compared to betulinic acid, of their ability to trigger the mitochondrial apoptosis pathway in various types of cancer cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00248C

Reference42 articles.

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2. Apoptotic Pathways and Therapy Resistance in Human Malignancies

3. Caspase-8 and Bid: Caught in the act between death receptors and mitochondria

4. The Warburg effect and mitochondrial stability in cancer cells

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