Di-mannosylation enhances the adjuvant properties of adamantane-containing desmuramyl peptides <i>in vivo</i>-Reference-Cited by-同舟云学术

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Di-mannosylation enhances the adjuvant properties of adamantane-containing desmuramyl peptides in vivo

Published:2024 Issue:32 Volume:22 Page:6506-6519
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Paurević Marija¹^ORCID,Maršavelski Aleksandra²^ORCID,Ivanković Siniša³,Stojković Ranko³,Ribić Rosana⁴^ORCID

Affiliation:

1. Department of Chemistry, Josip Juraj Strossmayer University Osijek, HR-31000 Osijek, Croatia

2. Department of Chemistry, Faculty of Science, University of Zagreb, HR-10000 Zagreb, Croatia

3. Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia

4. University Center Varaždin, University North, HR-42000 Varaždin, Croatia

Abstract

Mannosylation enhances the immunostimulating activity of MDP analogs, and the di-mannosylated derivative significantly increases the immunostimulation. The introduction of the second mannose contributes to the NOD2 binding affinity.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00592A

Reference45 articles.

1. Pattern recognition receptors in health and diseases

2. NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity

3. Membrane Association Dictates Ligand Specificity for the Innate Immune Receptor NOD2

4. Molecular Recognition of Muramyl Dipeptide Occurs in the Leucine-rich Repeat Domain of Nod2

5. Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their In Vivo Adjuvant Activity

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