A full conformational characterization of antiandrogen cortexolone-17α-propionate and related compounds through theoretical calculations and nuclear magnetic resonance spectroscopy-Reference-Cited by-同舟云学术

A full conformational characterization of antiandrogen cortexolone-17α-propionate and related compounds through theoretical calculations and nuclear magnetic resonance spectroscopy

Published:2014 Issue:7 Volume:5 Page:904-914
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Ferraboschi Patrizia¹²³,Legnani Laura¹²³⁴⁵,Celasco Giuseppe⁶⁷,Moro Luigi⁶⁷,Ragonesi Laura⁶⁷,Colombo Diego¹²³

Affiliation:

1. Dipartimento di Biotecnologie Mediche e Medicina Traslazionale

2. Università di Milano

3. 20133 Milano, Italy

4. Dipartimento di Chimica – Università degli Studi di Pavia

5. 27100 Pavia, Italy

6. Cosmo Research & Development S.p.A.

7. 20020 Lainate, Italy

Abstract

Theoretical calculations and NMR analyses were used in order to conformationally characterize the topical androgen cortexolone-17α-propionate (red shading) in comparison with other steroidal androgens and antiandrogens.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C4MD00049H

Reference19 articles.

1. Cutaneous Androgen Metabolism: Basic Research and Clinical Perspectives

2. Circulating testosterone, sex hormone binding globulin and prolactin in women with late onset or persistent acne vulgaris

3. Alopecia and Hirsuties

4. Differential Rates of Conversion of Testerone to Dihydrotestosterone In Acne and in Normal Human Skin- a Possible Pathogenic Factor in Acne

5. Testosterone Metabolism in the Skin

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Evaluation of in vitro Skin Permeation of Clascoterone From Clascoterone Topical Cream, 1% (w/w);AAPS PharmSciTech;2024-08-13

2. Quantum Chemical Computational Studies on the Structural Aspects, Spectroscopic Properties, Hirshfeld Surfaces, Donor-Acceptor Interactions and Molecular Docking of Clascosterone: A Promising Antitumor Agent;International Research Journal of Multidisciplinary Technovation;2024-07-12

3. The efficacy of Topical Clascoterone versus systematic spironolactone for treatment of acne vulgaris: A systematic review and network meta-analysis;PLOS ONE;2024-05-30

4. The cutaneous effects of androgens and androgen-mediated sebum production and their pathophysiologic and therapeutic importance in acne vulgaris;Journal of Dermatological Treatment;2024-01-08

5. Truncal Acne and Scarring: A Comprehensive Review of Current Medical and Cosmetic Approaches to Treatment and Patient Management;American Journal of Clinical Dermatology;2022-12-20