Copper-promoted direct amidation of isoindolinone scaffolds by sodium persulfate-Reference-Cited by-同舟云学术

Copper-promoted direct amidation of isoindolinone scaffolds by sodium persulfate

Published:2021 Issue:35 Volume:19 Page:7621-7626
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Lai Huifang¹^ORCID,Xu Jiexin¹,Lin Jin¹,Zha Daijun¹²^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Fujian Medical University, Fuzhou 350004, Fujian Province, China

2. Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University, China

Abstract

We described a copper-promoted direct amidation of isoindolinone scaffolds mediated by sodium persulfate. The amides, including primary and secondary amides, can be installed on isoindolinones in moderate to excellent yields by this method.

Funder

Fujian Medical University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01054A

Reference53 articles.

1. Metal-Free Synthesis of N-(Pyridine-2-yl)amides from Ketones via Selective Oxidative Cleavage of C(O)–C(Alkyl) Bond in Water

2. Methyl Esters as Cross-Coupling Electrophiles: Direct Synthesis of Amide Bonds

3. Amide Bond Bioisosteres: Strategies, Synthesis, and Successes

4. Visible-Light-Initiated Cross-Dehydrogenative Coupling of Quinoxalin-2(1H)-ones and Simple Amides with Air as an Oxidant

5. Catalytic amide formation from non-activated carboxylic acids and amines

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