Effect of geometrical constraints on human pluripotent stem cell nuclei in pluripotency and differentiation

Author:

Grespan Eleonora12345ORCID,Giobbe Giovanni G.12346ORCID,Badique Florent7891011ORCID,Anselme Karine7891011ORCID,Rühe Jürgen5121314,Elvassore Nicola12346ORCID

Affiliation:

1. Department of Industrial Engineering

2. University of Padova

3. Padova

4. Italy

5. Department for Microsystems Engineering

6. Venetian Institute of Molecular Medicine

7. University of Haute–Alsace

8. CNRS

9. IS2M UMR 7361

10. F-68100 Mulhouse

11. France

12. University of Freiburg

13. Freiburg

14. Germany

Abstract

Pluripotent stem cells are differentiated on microstructured substrates to investigate the nuclear deformability during differentiation and the role of mechanoregulating proteins.

Funder

Deutsche Forschungsgemeinschaft

Fondazione Cassa di Risparmio di Padova e Rovigo

Università degli Studi di Padova

Fondazione Telethon

Oak Foundation

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

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