HTE and machine learning-assisted development of iridium(<scp>i</scp>)-catalyzed selective O–H bond insertion reactions toward carboxymethyl ketones-Reference-Cited by-同舟云学术

HTE and machine learning-assisted development of iridium(i)-catalyzed selective O–H bond insertion reactions toward carboxymethyl ketones

Published:2023 Issue:5 Volume:10 Page:1153-1159
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Xu Yougen¹²,Ren Feixiao³,Su Lebin²⁴,Xiong Zhaoping³,Zhu Xinwei²,Lin Xinyuan³,Qiao Nan³,Tian Hao²,Tian Changen¹,Liao Kuangbiao²⁴^ORCID

Affiliation:

1. School of Life Sciences, Guangzhou University, Guangzhou 510006, China

2. Guangzhou, Laboratory, Guangzhou 510320, China

3. Laboratory of Health Intelligence, Huawei Cloud Computing Technologies Co., Ltd, Guizhou 550025, China

4. Bioland Laboratory, Guangzhou 510005, China

Abstract

By combining HTE and machine learning technologies, an iridium(i)-catalyzed highly selective O–H bond insertion reaction of carboxylic acids and sulfoxonium ylides was developed, and an extensive reaction space exploration was accomplished.

Funder

Guangdong Basic and Applied Basic Research Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D2QO01954J

Reference46 articles.

1. Ruthenium-catalyzed oxidative transformation of alkenes to .alpha.-ketols with peracetic acid. Simple synthesis of cortisone acetate

2. Molecular modeling based approach, synthesis, and cytotoxic activity of novel benzoin derivatives targeting phosphoinostide 3-kinase (PI3Kα)

3. A New Route to Protected Acyloins and Their Enzymatic Resolution with Lipases

4. Molecular Interactions of New Pregnenedione Derivatives

5. Synthesis and Biological Evaluation of Quinoline Salicylic Acids As P-Selectin Antagonists

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis of N-Aryl-4-trifluoromethylthiazol-2-amines via Insertion/Annulation of Trifluoromethylimidoyl Sulfoxonium Ylides with Sodium Thiocyanate;The Journal of Organic Chemistry;2024-08-16

2. Copper-Mediated Decarboxylative Coupling of 3-Indoleacetic Acids with Sulfoxonium Ylides for the Synthesis of α-Acetoxyl Ketones;Organic Letters;2024-07-11

3. Lithium Bromide-Promoted Formal C(sp³)–H Bond Insertion Reactions of β-Carbonyl Esters with Sulfoxonium Ylides to Synthesize 1,4-Dicarbonyl Compounds;The Journal of Organic Chemistry;2024-05-04

4. Metal-free cascade O–H double insertion between I^(III)/S^(VI)-ylides, carboxylic acids, and alcohols: modular access to unsymmetrical α,α-O,O-substituted ketones;Organic Chemistry Frontiers;2024

5. Rhodium(I)‐Catalyzed Asymmetric Hydroarylative Cyclization of 1,6‐Diynes to Access Atropisomerically Labile Chiral Dienes;Angewandte Chemie International Edition;2023-11-29