One-pot chemical pyro- and tri-phosphorylation of peptides by using diamidophosphate in water-Reference-Cited by-同舟云学术

One-pot chemical pyro- and tri-phosphorylation of peptides by using diamidophosphate in water

Published:2022 Issue:46 Volume:13 Page:13741-13747
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Lin Huacan¹^ORCID,Leman Luke J.¹^ORCID,Krishnamurthy Ramanarayanan¹^ORCID

Affiliation:

1. Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA

Abstract

An operationally simple phosphorylation of phosphopeptides by a one-pot sequential amidophosphorylation-hydrolysis protocol results in the synthesis of pyro- and triphosphopeptides with excellent chemoselectivity and good yields.

Funder

Simons Foundation

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC04160J

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