Mannose-mediated nanodelivery of methotrexate to macrophages augments rheumatoid arthritis therapy-Reference-Cited by-同舟云学术

Mannose-mediated nanodelivery of methotrexate to macrophages augments rheumatoid arthritis therapy

Published:2023 Issue:6 Volume:11 Page:2211-2220
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Yang Liang¹²,Sha Yongjie¹²,Wei Yuansong³,Fang Hanghang¹,Jiang Jingjing¹,Yin Lichen³^ORCID,Zhong Zhiyuan¹²^ORCID,Meng Fenghua¹^ORCID

Affiliation:

1. Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, P. R. China

2. College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, P. R. China

3. Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Collaborative Innovation Center of Suzhou Nano Science & Technology, Soochow University, Suzhou 215123, China

Abstract

Inflammation targeted delivery of methotrexate using mannose-installed polymersomes (Man-PMTX) can repolarize macrophages from M1 type to M2 type and mitigate proinflammatory cytokines, leading to effectively augmented rheumatoid arthritis therapy.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D2BM02072F

Reference38 articles.

1. Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis

2. Diagnosis and Management of Rheumatoid Arthritis

3. Methotrexate mechanism in treatment of rheumatoid arthritis