Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke-Reference-Cited by-同舟云学术

Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke

Published:2023 Issue:27 Volume:15 Page:11625-11646
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Wang Kai¹,Zhou Wentao¹,Jin Xiangyu²,Shang Xuwei¹,Wu Xiaomei¹,Wen Lijuan³,Li Sufen¹,Hong Yiling¹,Ke Jia¹,Xu Yichong¹,Yuan Hong¹⁴^ORCID,Hu Fuqiang¹⁴^ORCID

Affiliation:

1. College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, PR China

2. Department of Pharmacy, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China

3. National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, College of Pharmacy, Gannan Medical University, Ganzhou, 341000, PR China

4. Jinhua Institute of Zhejiang University, Jinhua 321299, China

Abstract

Hydroxyurea (Green dots) efficiently promoted regional cerebral blood flow and increased BBB permeability. Thereby, more hypoxia-sensitive liposomes NIPP/ER@HL-D were transported to lesions and entered brain to exert anti-stroke efficacy.

Funder

Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NR/D3NR01071F

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