Two-step, high-yielding total synthesis of antibiotic pyrones-Reference-Cited by-同舟云学术

Two-step, high-yielding total synthesis of antibiotic pyrones

Published:2024 Issue:3 Volume:22 Page:554-560
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hussain Akram¹,Sravanthi Revoju¹²,Katta Sunitha²,Ramachary Dhevalapally B.¹^ORCID

Affiliation:

1. Catalysis Laboratory, School of Chemistry, University of Hyderabad, Hyderabad-500 046, India

2. Pharmacognosy and Phytochemistry Division, Gitam Institute of Pharmacy, Gitam Deemed to be University, Visakhapatnam, 530 045, Andhra Pradesh, India

Abstract

A simple two-step dialkylation protocol was developed to synthesize antibiotics photopyrones, pseudopyronines, and violapyrones from triacetate lactone in excellent yields.

Funder

Science and Engineering Research Board

University of Hyderabad

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D3OB01923C

Reference44 articles.

1. Intrinsic Ability of the β‐Oxidation Pathway To Produce Bioactive Styrylpyrones

2. A novel and widespread class of ketosynthase is responsible for the head-to-head condensation of two acyl moieties in bacterial pyrone biosynthesis

3. Natural and synthetic 2H-pyran-2-ones and their versatility in organic synthesis

4. Pyrones as bacterial signaling molecules

5. Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity

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