A molecular approach to rationally constructing specific fluorogenic substrates for the detection of acetylcholinesterase activity in live cells, mice brains and tissues-Reference-Cited by-同舟云学术

A molecular approach to rationally constructing specific fluorogenic substrates for the detection of acetylcholinesterase activity in live cells, mice brains and tissues

Published:2020 Issue:41 Volume:11 Page:11285-11292
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wu Xiaofeng¹²³⁴,An Jong Min⁵⁶⁷⁸⁴,Shang Jizhen⁹¹⁰¹¹¹²¹³,Huh Eugene¹⁴¹⁵⁶⁷⁸,Qi Sujie¹²³⁴^ORCID,Lee Eunhye¹²³⁴,Li Haidong¹²³⁴^ORCID,Kim Gyoungmi¹²³⁴,Ma Huimin⁹¹⁰¹¹¹²¹³^ORCID,Oh Myung Sook¹⁶⁶⁷⁸⁴^ORCID,Kim Dokyoung⁵⁶⁷⁸⁴^ORCID,Yoon Juyoung¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and Nanoscience

2. Ewha Womans University

3. Seoul 03760

4. Republic of Korea

5. Department of Biomedical Science

6. Graduate School

7. Kyung Hee University

8. Seoul 02447

9. Beijing National Laboratory for Molecular Sciences

10. Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry

11. Chinese Academy of Sciences

12. Beijing 100190

13. China

14. Department of Medical Science of Meridian

15. College of Korean Medicine

16. Department of Life and Nanopharmaceutical Sciences

Abstract

In this work, a new approach was developed for designing the representative P10 with high selectivity and sensitivity for imaging AChE activity in the cells and normal mouse brain.

Funder

National Natural Science Foundation of China

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC04213G

Reference56 articles.

1. hChAT: A Tool for the Chemoenzymatic Generation of Potential Acetyl/Butyrylcholinesterase Inhibitors

2. Acetylcholinesterase Is Increased in the Brains of Transgenic Mice Expressing the C-Terminal Fragment (CT100) of the β-Amyloid Protein Precursor of Alzheimer's Disease