Simple and effective route for synthesis of parvaquone, an antiprotozoal drug-Reference-Cited by-同舟云学术

Simple and effective route for synthesis of parvaquone, an antiprotozoal drug

Published:2014 Issue:102 Volume:4 Page:58214-58216
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Patil Pravin C.¹²³,Akamanchi Krishnacharya G.¹²³

Affiliation:

1. Department of Pharmaceutical Sciences and Technology

2. Institute of Chemical Technology

3. Mumbai-400 019, India

Abstract

Parvaquone, an antiprotozoal agent is made from 1-naphthol and cyclohexanol in 33.8% overall yield in four steps: a novel acid catalyzed cyclohexylation to get 2-cyclohexyl-1-naphthol in 86% followed by oxidation, epoxidation and isomerization.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA09934F

Reference18 articles.

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2. R. H. Thomson , in Naturally Occuring Quinones IV, Blackie Academic, London, 1997

3. Anti-Cancer Activities of 1,4-Naphthoquinones: A QSAR Study

4. Hydroxyquinones: Synthesis and Reactivity

5. Theileria: intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks

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