A novel indomethacin/methotrexate/MMP-9 siRNA in situ hydrogel with dual effects of anti-inflammatory activity and reversal of cartilage disruption for the synergistic treatment of rheumatoid arthritis-Reference-Cited by-同舟云学术

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A novel indomethacin/methotrexate/MMP-9 siRNA in situ hydrogel with dual effects of anti-inflammatory activity and reversal of cartilage disruption for the synergistic treatment of rheumatoid arthritis

Published:2020 Issue:15 Volume:12 Page:8546-8562
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Yin Na¹²³⁴,Tan Xinyi¹²³⁴,Liu Hongbing¹²³⁴,He Fengming⁵⁶⁷⁴,Ding Ning¹²³⁴,Gou Jingxin¹²³⁴,Yin Tian⁸²³⁴,He Haibing¹²³⁴,Zhang Yu¹²³⁴^ORCID,Tang Xing¹²³⁴^ORCID

Affiliation:

1. Department of Pharmaceutics

2. Shenyang Pharmaceutical University

3. Shenyang

4. China

5. School of Pharmaceutical Sciences

6. Xiamen University

7. Xiamen

8. School of Functional Food and Wine

Abstract

The D/siRNA-NGel was constructed to alleviate pain and swelling, delay the progression of RA, and reverse cartilage and bone disruption.

Funder

China Postdoctoral Science Foundation

Doctoral Start-up Foundation of Liaoning Province

Natural Science Foundation of Liaoning Province

Shenyang Pharmaceutical University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NR/D0NR00454E

Reference60 articles.

1. Evolving concepts of rheumatoid arthritis

2. Pathogenetic insights from the treatment of rheumatoid arthritis

3. Pro-and Anti-inflammatory Cytokines in Rheumatoid Arthritis

4. Nanotherapeutics relieve rheumatoid arthritis

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1. Nanotechnology-empowered combination therapy for rheumatoid arthritis: principles, strategies, and challenges;Journal of Nanobiotechnology;2024-07-22

2. Injectable Smart Hydrogels for the Treatment of Osteoarthritis;Injectable Smart Hydrogels for Biomedical Applications;2024-07-19

3. Drug Targeting and Nanotherapeutic Advancement in the Treatment of Rheumatoid Arthritis: Recent Progress in Drug Delivery Systems;Current Pharmaceutical Biotechnology;2024-06-20

4. Advances in local drug delivery technologies for improved rheumatoid arthritis therapy;Advanced Drug Delivery Reviews;2024-06

5. Microenvironment Responsive Hydrogel Exerting Inhibition of Cascade Immune Activation and Elimination of Synovial Fibroblasts for Rheumatoid Arthritis Therapy;Journal of Controlled Release;2024-06

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