A NIR, <sup>1</sup>H-NMR, LC-MS and chemometrics pilot study on the origin of carvedilol drug substances: a tool for discovering falsified active pharmaceutical ingredients-Reference-Cited by-同舟云学术

A NIR, ¹H-NMR, LC-MS and chemometrics pilot study on the origin of carvedilol drug substances: a tool for discovering falsified active pharmaceutical ingredients

Published:2022 Issue:14 Volume:14 Page:1396-1405
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Raimondo Mariangela¹^ORCID,Borioni Anna¹,Prestinaci Francesca¹^ORCID,Sestili Isabella¹,Gaudiano Maria Cristina¹^ORCID

Affiliation:

1. Chemical Medicines Unit, Centro Nazionale Controllo e Valutazione dei Farmaci, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy

Abstract

The study explores the profile of carvedilol active ingredients by NIR, 1H-NMR and LC-MS Q-TOF and data were analysed by PCA, cluster analysis and PLSDA. Two different groups of manufacturers based on the geographical area are classified.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/AY/D1AY02035H

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